Here’s a fun bit of trivia (from an actual veterinarian):
One of the treatments for ethylene glycol (antifreeze) toxicity is good old ethanol. It’s a competitive inhibitor of ethylene glycol binding to alcohol dehydrogenase, thereby reducing the breakdown of ethylene glycol to it’s toxic metabolites (glocyaldehyde, glycolate, glyoxalate, and oxalic acid).
So… One of the solutions for a dog drinking toxic antifreeze is to get it drunk. Really drunk.
(and the dose is 5.5ml/kg IV q 4hrs for 5 treatments, then q6hrs for for four more treatments (20% solution, i.e. 40 proof vodka). [so, that’s a really drunk dog for almost two days…]
