Yeah, the amazing strains are what travel. Locally that became an epithet when the BC cops allowed indoor operations to go without enforcement and we got tons of warehouse weed. Beats bale / brick weed (which you can’t give away, let alone sell in the PNW) by a mile but that’s about all.
Acid is a weird one. The lasting (I wouldn’t mention trip/recover period, it goes without saying) psychological / cognitive damage I’ve seen has been both among the psychic warrior idiot “dude I just dropped a quarter sheet! lets go out and drink!” crowd, and among people who took the same (reasonable) amount of the same batch I and others did. I have always dismissed examination as impossible, you would have to figure out how much is mental vs physical, etc. I’ve made the assumption that some peoples chemistry (brain? endocrine? who knows…) is vulnerable. As for completely disintegrate I mean loss of job, loss of ability to keep such, sudden deficit in critical thinking / logic, loss of girl/boyfriend, place to live, etc. Moving from an intellectually and socially high functioning individual to a marginalized, going to need societal / institutional help individual. Rare, but random and awful to see.
Source - I spent a couple decades immersed in psychedelic / drug culture, using, selling, buying, and generally having a bloody good time with Thikal & Phikal as a “designer” bucket list, lsd, mushrooms of a variety of types, marijuana as a constant, ecstasy, amphets, and some prescription drugs. 
The new crop of synthetic “analogue” drugs I don’t touch. No two formulations are the same, and the formulations change as the US fed adds the new chemicals to the drug enforcement schedule. Add to that these are likely being made with god knows what industrial chemical supplies in ill measured batches in some outhouse. Oops, spilled a bit too much of w/e in that bucket? Oh well. Not quite enough battery acid to finish this batch? Well I have to piss anyways… I don’t believe for a second their labeling is accurate. As for discussion, the vast majority are unstudied in animals, let alone humans.
