Not really. The nice thing about acrylic, as us ex-electronic-tech types remember, is that it doesn’t adhere unreasonably to metal and is fairly brittle; you can chip it free fairly easily when you need to. (At least that’s true on normal-sized screws with traditional heads; dunno about the tiny stuff.)
If it bothers you, slap a tamper-evident label over the opening and then paint the randomizer across that…?
