I went through “the search” multiple times for my brother and my ex wife. It is a nightmare - living hell really - for family. How it ended is private. But I am now trying to help a friend in the same situation. Heroin, a missing daughter and around the same age. Xeni…please tell your friend(s) that to search now is important and justified. Reaching out like this is commendable too 
However, ask them to hold on to faith and hope as they will need that to counter the fear. Often people who run away, especially when addiction and/or mental illness is involved, are too lost in fear and pain to reach out. They “vanish” because they are going to ground. In my friends case, her daughter just showed up (in court, but alive) last week after going missing last Oct. There is hope.
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