I was thinking more along the lines of us loosing unrestrained Von Neumann probes on an expanding sublight sphere of of space - or some similarly catastrophically stupid act - and quite possibly in the process being the extinction event of non-engineering life that can’t defend itself, that is to say “primitive” life.
In the decreasingly likely event that there are civilizations such as we think of them in reach of such a sphere, they’ve probably been around a lot longer than we have, or at least will have been when that hypothetical extinction sphere reaches them, and therefore have taken or will take precautions against that eventuality. But to be clear, I don’t believe humans as we are will populate the universe in any significant presence. As we’ve amply demonstrated with Earth’s oceans though, we don’t need to be able to live somewhere to royally fuck it up.
We’re a pathogen, and if we want to keep our civilization and not be laid low, we have to find a way to stop being a pathogen. I have no idea if we’re up to the task. I hope so, but the current outlook is not good.