First official trial since the drug war banned them. Human trials have been going on for decades in the West, some of it organized research (like Leary and friends at Harvard), much of it informal self-experimentation. (And of course, the traditional healers we got the stuff from have been using it for much longer, though most of it was probably for the psychedelic effects.)
The traditional way to titrate dosages for marijuana (eat 1/4 of the cookie, wait an hour, have more if you want it) don’t really apply for psilocybin and LSD - taking a dose seems to block much of the effect of later doses - but people have also been doing a lot of recent experiment with “microdoses”, 1/10 - 1/4 of what it takes to get perceptual effects. With mushrooms, that’s pretty easy, since the typical doses are a few grams. So try it, and if you had a solid trip, wait a week, and if not, at least wait a few days.
I don’t know how you’d microdose with typical blotter LSD unless you’ve got a reliable long-term source; you’re buying a square of paper from some dude in the park that might have nothing in it, might have a lot, probably has it evenly distributed across the paper but maybe not – that’s something that actual medical researchers can do a lot better.
