You might as well replace ‘likelihood’ with ‘certainty’. They probably won’t use anything fundamentally proprietary (designing your own high speed bus and convincing, say, GPU or RAM manufacturers to use it would be so expensive as to defeat any possible benefits from lock in); but oddball custom mechanical connectors are your only option to build a system like this.
Desktop PCs are more or less wholly standardized (with the exception of the CPU/chipset interconnect, which is proprietary in Intel’s case and ‘standard’ with proprietary sauce in AMD’s; but is always used to connect the manufacturer’s CPU to the manufacturer’s chipset, so incompatibility is not terribly noticeable.); but a full PC incorporates quite a few different standardized connections, most not terribly amenable to ‘just replace magic module A with magic module B!’ type upgrades.
It’s a neat looking case; but it’s a hell of a lot of packaging to buy, and re-buy, in an effort to save ten minutes with a screwdriver…