National Cancer Institute director, in email to staff, warns of increasingly dire effects of shutdown on science

This is not just a problem NCI, this is affecting all Federal research funding orgs. The silent killer though is that the funding we receive has been piecemealed out for the past couple of years because Congress has been unable to pass a budget on time. Instead they have been providing funding in bits and pieces. It is very hard to provide consistent, long term research funding when you are unsure how much funding you will be getting and when it will come in. It also means that we have to do a new contracting action for temporary budget. This increase in volume gums things up and makes it more unpredictable for the universities and companies we fund.