The Portland metro area contains 40% of the state’s population–closer to half if you include L/A (which is reasonable, since it’s half an hour up the road and a lot of folks commute from L/A down to Portland).
Folks in the red counties aren’t going to change their votes. Their problem with Susan Collins isn’t that she votes with Trump 67% of the time; it’s that she doesn’t vote with him a third of the time. This is an ad directed at the George H.W. Bush republicans who live along the coast. As such, using four seconds of Portland flyover in a minute-long ad isn’t going to alienate the people they’re trying to reach.