Yes, I understand our neolithic cultivated plants and animals are not identical to wild ones. But that doesn’t mean eating plants and animals is futile so let’s just go for the all-fructose, gluten and margarine diet because everything is ‘processed’ anyway.
That talk is an interesting mix of real science and weird vegetarian bias (“we have no fangs so meat is wrong”). What it certainly is not is the ‘James Randi exposes the fraud’ style debunking it sells itself as. I think it’s very telling that her own guidelines on how to actually eat healthy (eat a diversity of whole, fresh and in season foods instead of focusing on nutrients and calories, care for your gut flora) is much more closely aligned to the recommendations promoted in most real paleo approaches than the odd, supposedly ‘paleo myths’ she does debunk.
If anyone cares for a thorough, level-headed and paleo-minded response to that talk, I recommend the one below in either text or annotated video versions. Don’t worry, you can leave your skeptic’s hat on.