I’m sorry, but unless you can provide a credible source, I call this bullshit. Especially esomeprazole having half the side effects. No way.
I’m having trouble finding a plain head-to-head study with tolerability data. This is the best I came up with, a fairly recent meta-analysis:
https://www.nature.com/articles/srep41021
Altought for a having the word “tolerability” in the title they don’t really give useable information about that.
“In terms of tolerance, the comparison results among active drugs did not reach statistical significance; however, the tolerance was better than the placebo (Fig. 7).”
So very little if any difference? I’d need quart of rum to get the patience to squint through all of that to know how trustworthy it is. A lot of big words though, seems good.
Also they do say this in the conclusion:
"This study indicates that the full/standard doses (40 mg per day) of esomeprazole should be recommended as first-line treatments for GERD in adults based on 4–8 weeks of short-term therapy for healing. Moreover, the full/standard doses (40 mg per day) of omeprazole were associated with the relief of symptoms and were well tolerated. "
You’d think that if there was a major difference in tolerability, it would have come up.
I’d say this is the same enantiomer trick that pharmacetuical companies did with citalopram/escitalopram and loratadine/desloratadine. It’s basically a smoke screen to extend the patents.
