I could see a “stab-only” staple providing compression if the bridge between the legs has a ratcheting feature like a zip-tie.
Yeah, that’s a tough one unless you really control the conditions. Internal bioabsorbance is relatively easy to control: environment is wet, slightly basic (unless in the stomach) and 37 degrees C. Cutaneous conditions vary wildly. Dry to wet. Hot to cold. Acid to base.