That’s what snags me. Naloxone is an inverse agonist—not just an antagonist—of mu-opioid receptors. And given its efficacy, probably a noncompetitive one at that.
Fluoxetine, at least what I know of it, doesn’t have any such mechanism. Direct mechanism, anyway. It’s plausible that it has an effect on second-messenger systems that somehow blunts response to MDMA, but that’s just a conjecture.
One thing I can say—from experience, not journal articles—is that mirtazapine will bail your ass out of a bad shroom trip in no more than fifteen minutes and will absolutely steamroll any nausea you might have had.
