Prozac mainly blocks reuptake of serotonin (though it does act as a weak antagonist at the serotonin 2C receptor). MDMA blocks reuptake and acts as a full agonist at serotonin receptors. Big difference. And at recreational doses, it does this so well that it induces downregulation (read: winnowing) of those serotonin receptors. With enough recreational doses, this downregulation can become permanent.
Therapeutic doses of MDMA are much lower though, to my knowledge, the peer-reviewed research studying its clinical efficacy for depression hasn’t yet determined its therapeutic index.
My advice: skip the party, take some shrooms with a good friend, and go for a stroll in the meadows.
