So it is one of the reasons Pluto doesn’t fit in well with the planets of our solar system, but really it’s a symptom of it being a smaller belt object, the sort that are easily scattered from the main plane. In our solar system nothing has pulled the eight largest masses away from that.
That doesn’t have to be the case though; you could easily have a planetary system disrupted by for instance a nearby star where even large planets are thrown out of alignment. This isn’t the first one they’ve found…for instance Upsilon Andromedae has planets much larger than Jupiter tilted about 30° apart. But I guess this one is particularly dramatic.
For the record, the smallest of the three planets here is listed as being about 5 times as massive as the Earth…so over 2000 times as massive as Pluto and obviously going to be very unlike it, even in terms of how their orbits relate to the rest of the system.