Synthetic biologist Floyd Romesberg is developing a third, artificial base pair for DNA

Australian SF writer Greg Egan wrote a short story called “The Moat” about a crime scene investigator who couldn’t work out why the sperm sample from a rape kit wasn’t showing any DNA results, only to realise that the rapist was a member of the zotta-rich who had his base pairs swapped out to make him immune to all known diseases.

It is available in his short story collection “Axiomatic”

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