I’ve done some long distance hiking (never more than a month at a time) and once you get your “trail legs” it’s not that hard to do 20 miles a day particularly if you’re not carrying a heavy pack. Certain sections of the A.T. are very easy because there’s not much change in elevation (MA and CT.) The changes in elevation in NH and southern Maine are brutal.
Trail running bothers me just because you’re asking to twist an ankle miles from a road, the trails are criss-crossed by lots of tree roots slick from thousands of boots.