DMT is a fucking awesome drug, when you just smoke it by itself, but ayahuasca sounds pretty risky. I’m well past the point in my life where I think it would be a good idea to take an MAOI inhibitor at all, much less mix it with anything physiologically active.
But, you know, each to their own…
I knew a guy a long time ago who did one of those rituals and came back with a nigh-unto-incurable strain of giardia.