In casual conversation, I avoid using “up” or “down” unless others get stubborn about it. They seem like Flatland orientations to me. People often seem vague about whether or not they are talking about position relative to themselves, or gravity. So I use in/out as more appropriately three-dimensional directions. For whatever has the strongest local gravitational effect - your gravity well, if you have one - “in” orients to its center, and “out” orients away from it.
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