This is basically my post doc work.
Although they did a poor job referencing, since none of the work by the group I worked with (who invented SERS, the nanosphere lithography process, AND the first in vivo SERS).
The idea of using a frequency shift, rather than amplitude is an interesting idea (same advantages in FM vs AM radio), but if I’m going to do that, then I’d just do a regular LSPR absorbance shift, save the money on a Raman rather than regular old spectrometer, and the step of adding that bound reporter molecule.
