I’m going to have to say ‘one of everything’.
I mean, my mind’s only so big, and while meditation and various other non-chemical state altering things can be useful, when working on something complicated I tended to make it a habit to push my limits about (safely, of course, but the legal drugs like alcohol (and Fox News) are kind of the worst of the bunch in most cases)). I’ll often look at a problem, alter my state, and look at it again from a different angle, write things down, re-read, and so on. It’s like being a one-person project team some times, except without the communication issues.
So . . . Adderall was useful for some things, better for structure, helps with memorization, but hurt lateral thinking and creativity some, Phenibut is an AMAZING anti-anxiety nootropic and has it’s own minor suite of effects, cannabis definitely has it’s uses, as do the ‘tams (though really they all feel just like Piracetam to varying degrees), I haven’t dabbled in shrooms in a while and I’d give a lot for a couple more goes with LSD (which was freaking USEFUL! . . but its’ sadly been almost a decade). There are plenty of natural things with useful effects too.
No real use for the depressants though, I don’t get much useful out of them that I can’t duplicate with a small amount of alcohol, and really the odds of me solving a problem with them have been pretty slim. Still, have had an occasional gem and a combination of a drunk friend and a mildly buzzed self mishearing him gave us our proxy-authority system for the coopernation, so I can’t write it off completely.
I mean, our brains are the only things we are supposed to completely own, right? Why not hack the heck out of them?