Sam Harris had already eloquently noted a leading set of candidate circumstances:
It is imperative that we begin speaking plainly about the absurdity of most of our religious beliefs…I pray that we may one day think clearly enough about these matters to render our children incapable of killing themselves over their books. If not our children, then I suspect it could well be too late for us because while it has never been difficult to meet your maker, in fifty years is will be simply be too easy to drag everyone else along to meet him with you.