One of my first thoughts was that since humans are so completely products of our environment, it’s likely that any future creature that could survive on another planet would likely not be human. Either we evolve or we force ourselves to evolve to another environment. All sorts of potential weirdness and ethical issues to unpack in that scenario. But I can’t help but think of Man Plus by Frederick Pohl, and the issues it brings up. I think I agree with you that I’m not sure humanity as a whole is brave enough to go that direction, considering the kerfuffle that comes with something as comparatively trivial as GMO crops.
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