I don’t believe in any particular “human nature”. But humans can certainly be modified by technology. How about trying to form human brains based more upon expanded orangutan or bonobo structures, to reduce that chimpish violent ego assholism?
What boggles me about human nature advocates is that they acknowledge physical changes to people are possible. Even most stodgy people who decry some human behavior as “unnatural” will still enjoy other unnatural conveniences like cars and medicine. Yet there is an insistence in many quarters that the biology of the human brain/mind cannot possibly be changed, so we shouldn’t even try.
It might not be a panacea, but you try a few things and see what works. Humans are a syncretic colonies of nanotech, they are anything but immutable.