As an autistic person, I'm not a big fan of that comparison.
A lot of people (not necessarily you) defend the interface as being part and parcel of the game's legendary difficulty. I think that's facile. The difficulty comes (or should come) from tantrums, lack of resources, zombie elephants, sudden horrible pick-a-part monsters, accidental lava floods, and all the other fun, emergent, characterful things that make Dwarf Fortress so unique. The interface ought to get out of the way and let you march smoothly onwards to complete, ignominous screwage without holdups or barriers.
Basically, I should be losing because of the game, not because of the interface.