That's the rub, though. If you're a theist, there IS getting away from that fact. There is an all-knowing, all loving, infinite cosmic mind who is with you in the most intimate and personal way from before you are conscious to after.
The world Pope Francis has faith in is a world in which none of us are ever as alone as we fear we are.
You can view this in a humanist light, too, though. Even without a god, our isolation is a shared experience -- we all know that ultimate cage of our own minds. That's something you and me and Hitler and Mao and Che and Mother Theresa and the Prophet Muhammad (PBUP) all share, as human beings.
Lonliness is, on some level, just a failure to notice the waters in which you swim.