I first read Illuminatus! in 1979, when I was 13 years old. I found the Cosmic Trigger a year later, along with Right Where You Are Sitting Now and Schroedinger's Cat. RWYASN was much more eye-opening than Cosmic Trigger, because by then I'd heard Leary's "You can only take the journey alone" speech, but RWYASN sat back and said, "No, you don't have to do this alone. There are others out there on the same journey. Find them."
The energy it takes to leave this planet is so overwhelmingly, economically devastating we'll never be doing it in large numbers, and the human body is so excessively optimized to its biosphere and vice-versa that carrying even a small analogue of it out into space is also economically unfeasible. There are hard numbers we're up against. If we leave this world, it won't be in vessels made out of meat.
RAW taught me a lot, but he also told me to use the spreadsheets. Our future is much more Greg Egan vs Aldous Huxley than it is Tim Leary vs. George Orwell.