What is the third biggest cause of death in the US?

Small bits of wood?

Very small rocks.

Churches!

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Just no. You actually provided the data to prove that you’re wrong. 458 deaths a year due to hepatotoxicity due to acetaminophen overdose per year is notable, but a drop in the bucket compared to opioid overdose deaths. Hospitals, pharmacies, hell even libraries aren’t stocking naloxone to reverse the effects of acetaminophen. The opiate is the leading cause of death, ERs are being bombarded with patients in respiratory distress which has everything to do with the opiate and nothing at all to do with the acetaminophen. You better bet hospitals and coroners would be listing hepatotoxicity as the cause of death, but they aren’t because that’s not what’s happening. The leading drugs for opiate overdose (methadone and oxycodone) don’t even contain an acetaminophen component. If you want to talk NSAIDs, more patients die each year from GI bleeds due to ibuprofen than die of hepatotoxicity due to APAP.

https://www.cdc.gov/drugoverdose/data/overdose.html

I try not to mix the nebulous term opioid and
the precise term opiate, because it obfuscates issues.

458 deaths a year - which is basically a minimum - means Tylenol poisoning has killed more people than terrorism over the last few decades, and we’ve spent billions of dollars to fight that.

But I do understand the purposeful toxicity of drugs like Vicodin is only a minor evil compared to the moral panic over opioids.

Trafficking in illegal opiates - heroin principally - is effectively being sponsored by drug warrior legislation that restricts physicians’ ability to prescribe unadulterated opiate painkillers legally. We know, with great certainty, that the heroin trade increases whenever such legislation is enacted. Cause -> effect. Such legislation causes great harm.

Incidentally, I already know about Ibuprofen induced internal bleeding, because my guts haven’t been quite the same since I had that very problem quite a few years ago. I got it from high doses of motrin… which I was prescribed because local doctors no longer prescribe safer opiate painkillers - such as codeine - which are over the counter non-prescription drugs in other countries.

And since the increasingly expensive drugs I’m being prescribed don’t work (I’m lucky to have insurance, but I’ve already spent thousands of dollars) now the doctors want to make injections directly into my brain. And - I shit you not - ECT has been mentioned.

Personally, I don’t want any heroin. Like many of the people who have died of illegally obtained opiates, I just want to freely buy a medicine that lets me continue to be a healthy taxpaying productive member of society. But that’s becoming increasingly difficult.

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Seeing that they used the term biggest, rather than widespread, I would’ve gone with this:

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