I have an autographed Problem Sleuth print on my wall, but Homestuck is something I stuck with only because it became one of those things that I'd gotten too far into and that I needed to see how it ended. I still have no clear idea exactly what was going on one-third of the time and I doubt there are any answers forthcoming (though I expect there most certainly will be an epilogue that will only create more questions).
There are times where it seemed very much like Hussie was quite literally banging his fingers on the keyboard and laughing at what came out. I think the high point might have been his tale of the bizarre alternate future where the Insane Clown Posse becomes presidents of the USA; it all seems so eerily prescient now.
TT: People were less prepared for a double juggalo presidency than they ever imagined.
TT: I'm not even going to get into all the horrifying details. Trust me, you just start to feel dirty reading about it.
TT: From the moment Fieri held up the bible to swear them in, and the three of them proceeded to publically defecate on it while freestyling rap lyrics...
TT: That was it. Everyone in the world watching it on TV just said, "Welp. Show's over. Civilization was pretty cool while it lasted."
I never read Dave Sim, but what I know of Cerebus led me to think that Homestuck was not entirely dissimilar in the sense that it felt like the product of an author who had become slightly unhinged and/or drunk with power.
I tried reading Dresden Codak. The one-offs are quite brilliant, but much of the rest of the content appears to be flagrantly self-indulgent, pretentious, and incomprehensible. Homestuck at least felt like something that was playing to some kind of community, but I can't see how Dresden Codak is supposed to work outside of the author's own mind.