Shaddam IV used spice to stay looking young. In the Lynch’s Dune, he’s 200, or something, but in the book, he’s in his seventies,
My father, the Padishah Emperor, took me by the hand one day and I sensed in the ways my mother had taught me that he was disturbed. He led me down the Hall of Portraits to the ego-likeness of the Duke Leto Atreides. I marked the strong resemblance between them—my father and this man in the portrait—both with thin, elegant faces and sharp features dominated by cold eyes. “Princess-daughter,” my father said, “I would that you’d been older when it came time for this man to choose a woman.” My father was 71 at the time and looking no older than the man in the portrait, and I was but 14, yet I remember deducing in that instant that my father secretly wished the Duke had been his son, and disliked the political necessities that made them enemies. —FROM “IN MY FATHER’S HOUSE”
Herbert, Frank. Dune (p. 171). Penguin Publishing Group. Kindle Edition.
An apt parallel might be Dracula-- who rediscovered part of his old youth and vitality after moving to London.