There is also trigeminal neuralgia, a nerve disorder that causes tremendous pain in the face.
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Before you read further, this is a bullshit article. I post it as a caution in reading articles of this sort.
Yes, it says antibodies fade quickly, citing a half-life of 73 days (news to me, but plausible) It then goes on to speculate that maybe that is not so bad as it looks, without citing any data or studies to back that statement. I certainly hope this speculation is correct, but for folks who donāt read critically, it reads as though this is a known thing. It is not. This kind of reporting is irresponsible at best.
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If Walmart offered a 50 cent discount to anyone who wore a mask from the time they entered the store until they left, these guys would be masked up the whole time.
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Iāve had that. It is excruciating, but not something that would keep you from being able to wear a mask.
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Who is this guy, and what have they done to the real Donnie?
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Can anyone interpret this? It sounds like good news.
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Maybe? The trouble is trying to project long term outcome on short term data. We have one dataset showing that asymptomatic to mildly symptomatic people generate antibodies that start to fade after about 2 months. This study funds that in mild to moderate cases (note slightly different population) antibodies seem to be stable up to 3 months. More severe infection may generate more durable immunity, or the difference in these duration data may be statistically similar. As always, WDKS and more info is needed.
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Le sigh.
Thanks!
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SPORTS!
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Maggie K, well beloved to members of the bbs, has an article on the balancing of risks and activities.
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And who gives a flying fuck?
Seriously, though, heās floundering, trying anything that might improve his polling numbers.
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Ted Bundy urges Americans to not get into cars with strangers, says he will rape and murder more people ābefore he is caughtā
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And finally, terminal cases guarantee no recurrence.
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The high seroprevalence at the start of the study makes me wonder about false positives in the ELISA. I didnāt see discussed any attempt to confirm ELISA with a virus neutralization test. Since the plasma in the study was collected for a (separate) convalescent plasma study, they have to have run VNT on some subset of the samples, I presume, so perhaps this information was omitted from the preprint. (Or is it even possible to do neutralization tests at this point? Do we have 2019-SARS-CoV-2 growing stably in cell culture?)
Even if the neutralizing antibody response fades, thatās not that great a surrogate for patient immunity. We use it because we can measure it. Few patients immunized against smallpox have any measurable level of circulating antibodies after a year, but the immunity (thought to be CD8+ T-cell-mediated) lasts for decades.
Of course, CD8+ T-cell-mediated immunity wonāt have any effect on convalescent plasma, since the cytotoxic lymphocytes arenāt being transfused, so itās meaningless for the real purpose of the Mount Sinai study.
As you say, WDKS.
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Since March here, probably in other level 3 containment facilities. (Tricky times for those facilities. They donāt want anything to get out, and they donāt want anything brought in either.)
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Sorry I didnāt make myself clear - emphasis was on the āstablyā. I know we have it growing in culture; is its infection and replication rate stable enough to support quantitative neutralization studies?
Iāve worked from time to time in BSL-3 facilities. (Iām not a biologist. Iām an electronics geek with a seriously weird gig.) Itās always a tricky time. 2019-SARS-CoV-2 might be new, but strange and deadly pathogens are those labsā stock in trade.
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Itās True! The data are skewed and falsified! (But not in the direction Il Douche seems to think)
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Here is a deeper dive into the immune response to covid, and some details of WDKS, but also some places that offer some encouragement. In the end, we are āgonna science the shit out of it.ā The question is what sort of timeline are we looking at, and that, for the time being, is truly an unknown.
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