The youtoob comments (I know, I know) several times touched on “eating it until drunk and red in the face”.
That made me curious, and I found stuff.
John Maninang and Hiroshi Gemma from the University of Tsukuba in Japan found that durian extract inhibited aldehyde dehydrogenase activity by up to 70%.
“Asian flush syndrome” is common among Asians of Chinese, Japanese and Korean descent.
Signs of Asian flush syndrome:
Due to genomic differences, most Asians have highly accelerated alcohol dehydrogenase, breaking down alcohol into acetaldehyde quickly.
Since alcohol is broken down faster it takes more drinking to get "right”.
But, also, most Asians have an inactive variant of the liver enzyme ALDH2. This means that the by-product acetaldehyde takes much longer to clear from their blood.
Acetaldehyde is more toxic than alcohol and a known cancer-causing agent.
It can trigger inflammation in the upper gastrointestinal tract, cause DNA damage, and increase one’s risk for gastrointestinal diseases, namely oesophageal and stomach cancers as well as peptic ulcers.
My slightly edumacated guess is, that depending on one’s genetic background one may or may not have serious health risks from mixing large amounts of durian with large quantities of alcohol.
Makes me wonder if our like or disgust for the fruit’s taste and smell in any way relates to the individually different levels of toxic effects it has on us.