This study says below. But - when I looked this med up when I took it for malaria- it has something like a 30 day half life? You don’t take it for more than a few days or your levels are through the roof.
“ Results. Hydroxychloroquine (EC50=0.72 μM) was found to be more potent than chloroquine (EC50=5.47 μM) in vitro. Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-CoV-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance”
Trump wants something that he can throw out right now, and who cares if it turns out to be ineffective. He’ll still take credit for everyone that gets better (i.e. lives), and the ones that died were probably nasty people, or so he heard.
Chloroquine (for malaria) is dosed 1 time per week for prophylaxis because it has a long half life. Hydroxychloroquine likewise. For treatment, the dosing is much higher and remains pretty safe. There are side effects, as with everything, but they are well understood and for most patients pretty manageable. I make it a policy to not base treatment strategies on a single paper. That said, unlike the newer drugs being studied, these have a long track record and are very well known, as well as inexpensive and readily available. I would certainly be willing to use it off-label after consultation with parents / patients, but stand by my statement that more study is needed. I am concerned that what will happen is a drug company will make some small twist and turn the cheap generic drug into an insanely expensive branded corona-specific drug. Would not be the the first time. (See ketamine)
Just because, I signed in to my Nextdoor account. There are multiple posts and info boxes about the "Help Map’, where neighbors who can help can sign in & see who needs help. After 2 days up, there are no posts on the map.
So their Help Map doesn’t help anyone.
Trump loves to trumpet that he’s a wartime president, but seems really reluctant to use his wartime powers.
Roosevelt made every American automaker retool for war production almost overnight. Surely Trump could make manufacturers work on producing masks, and other PPEs. We’re still a massive cotton producer.
Because for decades he was the only national level office-holding politician who was consistently against USian Worldwide Forever-war and one of the few who consistently gave a shat about deficits.
So, I have been largely incommunicado today as we made fairly huge changes at my office, which might be an idea worth duplicating, if any of you have input to pediatric practices in your areas. We have the privilege of having 2 physical locations, about 10 minutes apart. We have set up our main, larger office as a sick only office, and split that into respiratory illnesses on one side, all other illnesses on the other. The other office will be devoted to well child care, with a gatekeeper guarding the door, screening all who enter with temps and questions, including parents, siblings, vendors, whoever. Additionally we are now requiring all staff to arrive in street clothes, change into scrubs and work shoes at the office and change back before going home to protect our families and community from whatever we come into contact with. This is a huge logistical effort, and an inconvenience for our patients, but so far we have only gotten positive feedback. It is very real. And in Harrisonburg we are treating it as such.
As someone pointed out, anyone with experience making lingerie might be a good source of advice. Especially anything that needs to stick close to the skin and mould.
Wearing underpants on your head may become the smart move.
