Eminem and ICP definitely had a long-running beef going - they are both Detroit-area white rappers that were active at the same time. It was inevitable.
The story goes that when Eminem was up and coming that he tried to get ICP to appear at a party he was performing at and they told him to fuck right off. This kicked off a weirdly homophobic feud that went on for years. Eminem had a track where he claimed that him and other members of D12 chased ICP out of a club and shot their van with paintballs. ICP came back with a parody of “My Name Is…” called “Slim Anus” (which I always found odd phrasing given the homophobic slant of their attacks). They had numerous back and forth diss tracks over the years along with some real life altercations.
In 2005, the late Proof of D12 finally ended the feud with a bowling match between the two crews. (This is not a joke.)