Oy...this'll be showing my age all too embarrassingly, but I can think of at least three Americanized anime before BOTP–"Astro Boy" and "Kimba the White Lion", from Osamu Tezuka (in Japan, they were "Mighty Atom" and "Jungle Taitei"), sometimes referred to as "Godfather of Anime". (And Disney's "The Lion King" probably should have been sued for, um, "borrowing" VERY heavily from "Kimba".)
And "8th Man", a cyborg superhero who got his powers from smoking "energy" cigarettes (!).
The US versions were all from the early-to-mid '60s–one of our local Detroit independent TV stations broadcast them. Although "8th Man" wasn't without its charms (jesus–energy cigarettes?), the Tezuka shows are things of beauty, as are the multitude of manga he produced, some of it quite adult in content. (Not X-rated adult, just meant for adult consumption.)