https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00013-0/fulltext
Summary
Background
COVID-19 survivors may experience a wide range of chronic cognitive symptoms for months or years as part of post-COVID-19 conditions (PCC). To date, there is no definitive objective cognitive marker for PCC. We hypothesised that a key common deficit in people with PCC might be generalised cognitive slowing.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00442-3
Highlights
• hPSC-derived DA neurons are susceptible to SARS-CoV-2 infection • SARS-CoV-2 infection of DA neurons triggers cellular senescence response • Several FDA-approved drugs were identified to rescue senescence of DA neurons • Cellular senescence was found in substantia nigra tissues of COVID-19 patients
