If you understand German, go for this link to get an update on false negatives, positive re-testing, and re-infections from one of the top researchers on SARS and MERS.
If your don’t understand German, go for Google translate. Some details will be lost, but it’s much better than reading thoughts and opinions of random strangers on the internet.
ETA: @RickMycroft, disclaimer: your post just reminded me to post this. Nothing to do with you personally, just general advice.
Number of people with coronavirus infections may be dozens of times higher than the number of confirmed cases
An antibody study carried out by the Finnish Institute for Health and Welfare (THL) has found that the number of people infected with coronavirus in the Hospital District of Helsinki and Uusimaa (HUS) may be many times higher than the confirmed number of cases.
“ In 1963, he and his wife Gloria brought Bob Dylan to town for the first time, for a sparsely attended gig at the Ethical Society on Rittenhouse Square. In 1967, Joni Mitchell, who he called “the most creative person I ever met,” played “Both Sides Now” for the first time on his show.”
“ Shay would tell about meeting Charles Mingus at a restaurant in Chinatown, or giving Ramblin’ Jack Elliott a remedy for a cold that made the singer think the DJ was trying to kill him, or Jackson Browne playing a note perfect “For Everyman” on his show even though his fingers were covered in Russian dressing.
In 1957, Shay had a small role in The Burglar , a film noir based on a book by Philadelphia author David Goodis starring Jayne Mansfield.”
More bad news to go with yesterday’s reversal of downward trending mortality numbers:
Deets below to circumvent possible paywalling:
tldr; The primary coronavirus target is the lungs, but other organs are showing signs of attack; high rates of kidney failure not attributable to cytokine storm are of particular concern.
Even more alarming, he added, is early data that shows 14 to 30 percent of intensive-care patients in New York and Wuhan, China — birthplace of the pandemic — have lost kidney function and require dialysis, or its in-hospital cousin, continuous renal replacement therapy. New York intensive care units are treating so much kidney failure, he said, they need more personnel who can perform dialysis and have issued an urgent call for volunteers from other parts of the country. They also are running dangerously short of the sterile fluids used to deliver that therapy, he said.
“That’s a huge number of people who have this problem. That’s new to me,” Kliger said. “I think it’s very possible that the virus attaches to the kidney cells and attacks them.”
Obligatory note of caution regarding battlefield speculation:
But in medicine, logical inferences often do not prove true when research is conducted. Everyone interviewed for this story stressed that with the pandemic still raging, they are speculating with much less data than is normally needed to reach solid clinical conclusions.
Many other possible causes for organ and tissue damage must be investigated, they said, including respiratory distress, the medications patients received, high fever, the stress of hospitalization in an ICU and the now well-described impact of cytokine storms.
“It does raise the very clear suspicion that at least a part of the acute kidney injury that we’re seeing is resulting from direct viral involvement of the kidney, which is distinct from what was seen in the SARS outbreak in 2002,” said Paul M. Palevsky, a University of Pittsburgh School of Medicine nephrologist and president-elect of the National Kidney Foundation.
Any tissue containing ACE2 receptors is a potential target of the virus. It truly does not care. And that is a very widespread receptor in the body. This is an explanation (we think) for the late-onset cardiomyopathy that seems to be one of the causes of death in the late stages of this thing. Finding it in other tissues is not at all surprising.
Yeah it sounds like she thinks there have been 18 other ‘once in a hundred years’ pandemics, and somehow nobody noticed, and WHO’s at fault, because they’ve ‘should have enough practice by now…’